The questions in this quiz have been provided by Dr. Dominic Palazzolo, PhD.
Physiology Professor at LMU-DCOM
Gastrointestinal Physiology Quiz
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A 45 year old woman presents with dysphagia (difficulty in swallowing) for solid foods and liquids. A barium swallow reveals dilation of the proximal esophagus, and a beak-like tapering of the distal esophagus. You correctly diagnosis achalasia and fully expect to see all of the following characteristics EXCEPT:
increased tone in the lower esophageal sphincter (LES)
absence of a coordinated peristaltic effort down the esophagus
nonfunctional or absence of the esophageal intramural plexuses (i.e. ENS)
decreased amounts of skeletal muscle along the upper third of esophagus
simultaneous low pressure increases along the entire length of the esophagus during a swallow
Which of the following secretagogues or conditions is most likely to stimulate the secretion of cholecystokinin (CCK) from the duodenal mucosa?
free fatty acids
What is the most common type of motility associated with the descending colon?
You have sat down to a scrumptious meal consisting of a spinach salad, a juicy piece of very lean filet mignion (16 oz.), a baked potato with generous gobs of butter and sour cream, and a fine glass of a robust wine. Which of the following represents the BEST order in which the above items are sequentially emptied from the stomach?
fillet mignion, potato, wine, butter
wine, filet mignion, potato, butter
potato, filet mignion, butter, wine
wine, potato, filet mignion, butter
potato, wine, butter, filet mignion
Myenteric oscillation potentials are characterized as__________ slow waves which are ____________ likely to generate spontaneous action potentials.
High amplitude & low frequency - Less
High amplitude & low frequency - More
Low amplitude & high frequency - Less
Low amplitude & high frequency - More
Below is a list of events that occur during the act of vomiting.
- the LES and UES are open
- forced inspiration against a closed glottis
- reverse peristalsis from the mid small intestine
- the LES is open and the UES is closed
- relaxation of the pyloric sphincter
- forceful contractions of the stomach
Indicate the correct sequence of events involved in the act of vomiting
5, 3, 2, 6, 4, 1
3, 5, 6, 2, 1, 4
3, 5, 2, 6, 1, 4
5, 3, 6, 2, 1, 4
3, 5, 2, 6, 4, 1
Which gastrointestinal function IS NOT caused by cholecystokinin?
contraction of the bladder
increased rate of gastric emptying
increased secretion of pancreatic juice rich in digestive enzymes
potentiation of secretin-induced pancreatic secretion rich in bicarbaonate
potentiation of secretin-induced bile production
Which of the following IS NOT a function of hepatocytes?
active uptake of plasma bile acids
synthesis of primary bile acids from cholesterol
conjugation secondary bile acids
conversion of bilirubin to urobilinogen
secretion of bile acids into bile canaliculi
Which cells type is PROPERLY matched with its secretion?
Enteroendocrine cell - Trypsinogen
Chief cell - Intrinsic factor
Parietal cell – Gastrin
G-cell - Pepsinogen
Enterochromaffin-like cell - Histamine
By which mechanism of action does Cimetidine inhibit gastric acid secretion?
competing for the H2 receptor
competing for the M3 receptor
competing for the CCK-B/Gastrin receptor
blocking Ca4 channels
inhibiting the proton-pump
How does the autonomic nervous system affect salivary secretory rate?
Salivary secretory rate is increased in response to parasympathetic and sympathetic stimulation.
Salivary secretory rate is decreased in response to parasympathetic and sympathetic stimulation.
Salivary secretory rate is increased in response to parasympathetic stimulation and decreased in response to sympathetic stimulation.
Salivary secretory rate is decreased in response to parasympathetic stimulation and increased in response to sympathetic stimulation.
The transport of which substance IS NOT Na+-dependant?
Which bond is cleaved by the action of isomaltase?
α-1, 4 glycosidic bonds of maltose
α-1, 6 glycosidic bonds of α-limiting dextrins
α-1, 6 glycosidic bonds of maltriose
β-1,,4 glycosidic bond of trehalose
β-1, 6 glycosidic bond of lactase
Excessive absorption of which substance is responsible for hemochromatosis?
A 38 year old male walks into your office complaining of abdominal pain. An upper GI series revealed the presence of a gastric ulcer. Gastrin levels are 74 pg/ml (normal range is 50 to 150 pg/ml). Hydrochloric acid levels are 2mmoles/hr (normal range is 1 to 5 mmoles/hr). Blood analysis reveals elevated levels of macrophages and other immunocytes. From the given information, this individual is most likely suffering from ___________ which is best treated with__________.
Chronic Superficial Gastritis - antibiotics
Crohns*s Disease - somatostatin
Celiac Disease - opiates
H. Pylori infection - omeprazole
Gluten enteropathy - ipecac