Nephritic and Nephrotic Syndromes Quiz

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Question 1

What type of hypersensitivity is Goodpasture syndrome?

A	Type I
B	Type IV
C	Type II
D	Type III

Question 1 Explanation:

Goodpasture syndrome is a type II hypersensitivity with antibodies against the glomerular basement membrane.

Question 2

A woman with a history significant for lupus is found to have 2.3 grams of protein in her urine each day. In the investigation you find wire looping of the capillaries on light microscopy. Which of the following tops your differential?

A	Focal segmental glomerulosclerosis
B	Rapidly progressive Glomerulonephritis
C	IgA nephropathy
D	Diffuse proliferative glomerulonephritis

Question 2 Explanation:

Wire looping should be a term that you associate with Diffuse Proliferative Glomerulonephitis.

Question 3

Which syndrome shoes a spike and dome appearance on electron microscopy?

A	Goodpasture syndrome
B	Membranous glomerulonephritis
C	Berger's disease (IgA nephropathy)
D	Alport syndrome
E	Accute post streptococcal GN

Question 3 Explanation:

Membranous glomerulonephritis has a spike and dome appearance on EM. It is also the most common cause of adult nephrotic syndrome.

Question 4

Which of the following is NOT a part of the body affected in Alport syndrome?

A	Ears
B	Eyes
C	Liver
D	Kidneys

Question 4 Explanation:

Alport syndrome is a type IV collagen defect that leads to eyesight changes, deafness, and nephrotic syndrome.

Question 5

This image shows apple-green birefringence with Congo-red stain on light microscopy.

What nephrotic disease would you suspect?

A	Minimal change disease
B	Diabetic glomerulonephropathy
C	Wegener's granulomatosis
D	Amyloidosis

Question 5 Explanation:

Amyloidosis is associated with many chronic conditions, and is often described as "apple-green birefringence" on a Congo-red stain on LM.

Question 6

What is a defining feature of minimal change disease?

A	Blunting of the villi on light microscopy
B	Slight visible changes of the glomeruli on light microscoty
C	Segmental sclerosis on light microscopy
D	Effacement of the foot processes on electron mycroscopy

Question 6 Explanation:

Minimal change disease shows normal glomeruli on LM and effacement of the foot processes on EM. Minimal change is most often seen in children.

Question 7

Which nephrotic syndrome has a "tram-track" appearance on light microscopy?

A	Membranoproliferative glomerulonephritis
B	RGPN
C	Diffuse proliferative glomerulonephritis
D	Diabetic glomerulonephritis
E	Berger's disease

Question 7 Explanation:

Membranoproliferative glomerulonephritis has a "tram-track" appearance on LM. Diabetic glomerulonephritis is the only other answer that is a nephrotic syndrome, the rest are nephritic syndromes.

Question 8

Which nephrotic syndrome is associated with HIV?

A	Focal Segmental Glomerulosclerosis
B	Minimal Change Disease
C	Amyloidosis
D	IgA Nephropathy

Question 8 Explanation:

Focal Segmental Glomerulosclerosis is the most common glomerular disease in patients with HIV.

Question 9

A patient complains of excessively frothy urine when he uses the toilet in the morning. Thickening of the glomerular basement membrane and Kimmelstiel-Wilson lesions are seen on light microscopy.

What has been the major cause of this patients current condition?

A	Recent streptococcal infection
B	Poor control of glucose levels
C	SLE
D	Antibodies to the glomerular and alveolar basement membranes

Question 9 Explanation:

Kimmelstiel-Wilson lesions are a defining feature of diabetic glomerulonephropathy.

Question 10

Which of the following characteristics is used to define a nephritic syndrome?

A	Red Blood Cell casts in urine with a decreased BUN and creatinine
B	Fatty casts in urine
C	Polyuria and hypotension
D	Protein in the urine (under 3.5 grams per day)

Question 10 Explanation:

One of the defining features used to determine the difference between nephritic and nephrotic syndromes is the amount of protein in the urine. Nephritic syndromes have under 3.5 g/day. Nephrotic syndromes have over 3.5 g/day. Fatty casts are a feature of nephrotic syndromes.

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