Tumor Markers Quiz

Tumor Marker Quiz

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Question 1

Obstructive biliary disease and Paget's disease of the bone have which of the following tumor markers in common?

A
Calcitonin
B
Alkaline phosphatase
C
S-100
D
Tartrate-resistant acid phosphatase (TRAP)
Question 1 Explanation: 
Alkaline phosphatase is a marker for both obstructive biliary disease and Paget's disease of the bone. TRAP is associated with Hairy cell leukemia, and Calcitonin is associated with Thyroid medulary carcinoma.
Question 2

Which of the following cancers is NOT associated with β-hCG?

A
Gestational trophoblastic tumors
B
Choriocarcinoma
C
Prostate carcinoma
D
Hydatidiform mole
Question 2 Explanation: 
A helpful mnemonic for β-hCG tumors is HCG. H for Hydatidiform moles, C for Choriocarcinoma, G for Gestational trophoblastic tumors.
Question 3

What tumor marker is associated with melanoma?

A
TRAP
B
S-100
C
Alkaline phospatase
D
Bombesin
Question 3 Explanation: 
S-100 is associated with melanoma, astrocytomas, and Neural tumors.
Question 4

Which of the following tumor markers is/are associated with pancreatic cancers?

A
CA - 125
B
Calcitonin
C
CEA and CA-19-9
D
CA-19-9
E
CEA
F
CA-19-9 and CA-125
Question 4 Explanation: 
Pancreatic cancer can have CA-19-9 and CEA. Carcinoembryonic antigen (CEA) is associated with pancreatic cancers, colorectal cancers, as well as breast, gastric and thyroid medullary carcinoma. CEA is less specific than CA-19-9 for pancreatic cancers. Some cancers have more than one marker, and some markers have more than one cancer. Choosing CA-19-9 alone or CEA alone is not technically wrong, but selecting them together is more correct.
Question 5

What tumor marker is extremely elevated in a patient with a hydatidiform mole?

A
β-hCG
B
CA-125
C
α-fetoprotein
D
PSA
Question 5 Explanation: 
β-hCG is extremely elevated in these patients. Another classic finding is a "snow storm" appearance on ultrasound.
Question 6

Which of the following is found in patients with prostate carcinoma, but not in patients that only have benign prostatic hyperplasia?

A
Prostatic acid phosphatase (PAP)
B
Prostate specific antigen (PSA)
Question 6 Explanation: 
PAP is associated with protate carcinoma and not BPH. PSA is used to screen for prostate carcinoma and can also be elevated in BPH and prostatitis.
Question 7

What cancer marker is a associated with CA-125

A
Pancreatic cancers
B
Hepatocellular carcinomas
C
Surface epithelial tumors of the ovaries
D
Melanoma
Question 7 Explanation: 
CA-125 is associated with ovarian surface epithelial tumors. The CA-125 blood test is useful for a differential diagnosis and follow up for the disease, but it should not be used by itself for diagnosis due to low sensitivity and low specificity.
Question 8

Which childhood cancer has bombesin as a tumor marker?

A
Gastric cancer
B
Lung cancer
C
Acute lymphoblastic leukemia
D
Neuroblastoma
Question 8 Explanation: 
Neuroblastoma, lung cancer, and gastric cancer have bombesin as a tumor marker; however, neuroblastoma is the best answer because it is a childhood cancer (Lung and Gastric cancers are not common in childhood). Neuroblastoma is the most common extracranial solid cancer in childhood and the most common cancer in infancy. ALL is a childhood cancer, but it is not associated with bombesin.
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There are 8 questions to complete.