Tumor Markers Quiz

Tumor Marker Quiz

Please wait while the activity loads.
If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled.

If loading fails, click here to try again

Congratulations - you have completed Tumor Marker Quiz.

You scored %%SCORE%% out of %%TOTAL%%.

Your performance has been rated as %%RATING%%

Your answers are highlighted below.

Question 1

Which of the following cancers is NOT associated with β-hCG?

A	Gestational trophoblastic tumors
B	Choriocarcinoma
C	Prostate carcinoma
D	Hydatidiform mole

Question 1 Explanation:

A helpful mnemonic for β-hCG tumors is HCG. H for Hydatidiform moles, C for Choriocarcinoma, G for Gestational trophoblastic tumors.

Question 2

Which of the following tumor markers is/are associated with pancreatic cancers?

A	CEA
B	CA-19-9 and CA-125
C	CA-19-9
D	CA - 125
E	CEA and CA-19-9
F	Calcitonin

Question 2 Explanation:

Pancreatic cancer can have CA-19-9 and CEA. Carcinoembryonic antigen (CEA) is associated with pancreatic cancers, colorectal cancers, as well as breast, gastric and thyroid medullary carcinoma. CEA is less specific than CA-19-9 for pancreatic cancers. Some cancers have more than one marker, and some markers have more than one cancer. Choosing CA-19-9 alone or CEA alone is not technically wrong, but selecting them together is more correct.

Question 3

Obstructive biliary disease and Paget's disease of the bone have which of the following tumor markers in common?

A	Calcitonin
B	S-100
C	Tartrate-resistant acid phosphatase (TRAP)
D	Alkaline phosphatase

Question 3 Explanation:

Alkaline phosphatase is a marker for both obstructive biliary disease and Paget's disease of the bone. TRAP is associated with Hairy cell leukemia, and Calcitonin is associated with Thyroid medulary carcinoma.

Question 4

What tumor marker is associated with melanoma?

A	Bombesin
B	S-100
C	Alkaline phospatase
D	TRAP

Question 4 Explanation:

S-100 is associated with melanoma, astrocytomas, and Neural tumors.

Question 5

Which of the following is found in patients with prostate carcinoma, but not in patients that only have benign prostatic hyperplasia?

A	Prostate specific antigen (PSA)
B	Prostatic acid phosphatase (PAP)

Question 5 Explanation:

PAP is associated with protate carcinoma and not BPH. PSA is used to screen for prostate carcinoma and can also be elevated in BPH and prostatitis.

Question 6

What tumor marker is extremely elevated in a patient with a hydatidiform mole?

A	PSA
B	β-hCG
C	α-fetoprotein
D	CA-125

Question 6 Explanation:

β-hCG is extremely elevated in these patients. Another classic finding is a "snow storm" appearance on ultrasound.

Question 7

What cancer marker is a associated with CA-125

A	Pancreatic cancers
B	Hepatocellular carcinomas
C	Surface epithelial tumors of the ovaries
D	Melanoma

Question 7 Explanation:

CA-125 is associated with ovarian surface epithelial tumors. The CA-125 blood test is useful for a differential diagnosis and follow up for the disease, but it should not be used by itself for diagnosis due to low sensitivity and low specificity.

Question 8

Which childhood cancer has bombesin as a tumor marker?

A	Acute lymphoblastic leukemia
B	Lung cancer
C	Neuroblastoma
D	Gastric cancer

Question 8 Explanation:

Neuroblastoma, lung cancer, and gastric cancer have bombesin as a tumor marker; however, neuroblastoma is the best answer because it is a childhood cancer (Lung and Gastric cancers are not common in childhood). Neuroblastoma is the most common extracranial solid cancer in childhood and the most common cancer in infancy. ALL is a childhood cancer, but it is not associated with bombesin.

Once you are finished, click the button below. Any items you have not completed will be marked incorrect. Get Results

There are 8 questions to complete.