Tumor Markers Quiz

Tumor Marker Quiz

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Question 1

Which of the following cancers is NOT associated with β-hCG?

A	Prostate carcinoma
B	Hydatidiform mole
C	Gestational trophoblastic tumors
D	Choriocarcinoma

Question 1 Explanation:

A helpful mnemonic for β-hCG tumors is HCG. H for Hydatidiform moles, C for Choriocarcinoma, G for Gestational trophoblastic tumors.

Question 2

What cancer marker is a associated with CA-125

A	Hepatocellular carcinomas
B	Melanoma
C	Pancreatic cancers
D	Surface epithelial tumors of the ovaries

Question 2 Explanation:

CA-125 is associated with ovarian surface epithelial tumors. The CA-125 blood test is useful for a differential diagnosis and follow up for the disease, but it should not be used by itself for diagnosis due to low sensitivity and low specificity.

Question 3

Which childhood cancer has bombesin as a tumor marker?

A	Gastric cancer
B	Neuroblastoma
C	Lung cancer
D	Acute lymphoblastic leukemia

Question 3 Explanation:

Neuroblastoma, lung cancer, and gastric cancer have bombesin as a tumor marker; however, neuroblastoma is the best answer because it is a childhood cancer (Lung and Gastric cancers are not common in childhood). Neuroblastoma is the most common extracranial solid cancer in childhood and the most common cancer in infancy. ALL is a childhood cancer, but it is not associated with bombesin.

Question 4

Which of the following is found in patients with prostate carcinoma, but not in patients that only have benign prostatic hyperplasia?

A	Prostatic acid phosphatase (PAP)
B	Prostate specific antigen (PSA)

Question 4 Explanation:

PAP is associated with protate carcinoma and not BPH. PSA is used to screen for prostate carcinoma and can also be elevated in BPH and prostatitis.

Question 5

What tumor marker is extremely elevated in a patient with a hydatidiform mole?

A	PSA
B	α-fetoprotein
C	CA-125
D	β-hCG

Question 5 Explanation:

β-hCG is extremely elevated in these patients. Another classic finding is a "snow storm" appearance on ultrasound.

Question 6

What tumor marker is associated with melanoma?

A	S-100
B	Alkaline phospatase
C	Bombesin
D	TRAP

Question 6 Explanation:

S-100 is associated with melanoma, astrocytomas, and Neural tumors.

Question 7

Which of the following tumor markers is/are associated with pancreatic cancers?

A	CEA
B	CEA and CA-19-9
C	Calcitonin
D	CA - 125
E	CA-19-9
F	CA-19-9 and CA-125

Question 7 Explanation:

Pancreatic cancer can have CA-19-9 and CEA. Carcinoembryonic antigen (CEA) is associated with pancreatic cancers, colorectal cancers, as well as breast, gastric and thyroid medullary carcinoma. CEA is less specific than CA-19-9 for pancreatic cancers. Some cancers have more than one marker, and some markers have more than one cancer. Choosing CA-19-9 alone or CEA alone is not technically wrong, but selecting them together is more correct.

Question 8

Obstructive biliary disease and Paget's disease of the bone have which of the following tumor markers in common?

A	Calcitonin
B	S-100
C	Tartrate-resistant acid phosphatase (TRAP)
D	Alkaline phosphatase

Question 8 Explanation:

Alkaline phosphatase is a marker for both obstructive biliary disease and Paget's disease of the bone. TRAP is associated with Hairy cell leukemia, and Calcitonin is associated with Thyroid medulary carcinoma.

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There are 8 questions to complete.